Table 3.

Nuclear TR mutant-associated proteins are in large protein complexes

Symbol	Protein name	Functions
CCAR1	Cell cycle- and apoptosis- regulatory protein 1; death inducer with SAP domain, DIS	Associates with components of the Mediator and p160 coactivator complexes and is a key regulator of mediator complex recruitment to NR target genes in response to the appropriate hormone; a novel component of Wnt/β-catenin signaling that plays an important role in transcriptional regulation by β-catenin.
CHD4	Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218-kDa protein) (Mi2-β)	Belongs to the SNF2/RAD54 helicase family; it represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression; interacts with RORγ and represses RORγ-mediated transcriptional activation.
FLNA	Filamin A, α isoform 2 (Endothelial actin-binding protein) (actin-binding protein 280) (ABP-280) (nonmuscle filamin)	An actin-binding protein; a 280-kDa protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm; participates in the anchoring of membrane proteins for the actin cytoskeleton; interacts with AR.
KIF11	Kinesin family member 11, kinesin-like protein KIF11 (Thyroid receptor-interacting protein 5) (TRIP)	A motor protein that belongs to the kinesin-like protein family; may be involved in various kinds of spindle dynamics including chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis; interacts with NCoR1 (Affinity-MS) and Thrb (yeast-two hybrid).
NCL	Nucleolin	A eukaryotic nucleolar phosphoprotein; involved in the synthesis and maturation of ribosomes; interacts with GR.
NONO	Non-POU domain- containing, octamer-binding	aka p54nrb (54 kDa RNA binding protein); plays various roles in the nucleus, including transcriptional regulation and RNA splicing; PSF and p54nrb (co-regulators) have also been reported to inhibit transcription by recruiting HDACs through mSin3A to other NRs including SF1, TRs, AR, and RXR; interacts with PR and acts as a corepressor.
SFPQ	Splicing factor proline/glutamine rich	aka PSF (polypyrimidine tract-binding protein-associated splicing factor); complexed with p54nrb; involved in transcription and RNA processing; directly interacts with PR and GR and specific co-regulatory proteins.
TBL1XR1	Transducin (β)-like 1 X-linked receptor 1	aka TBLR1; has sequence similarity with members of the WD40 repeat-containing protein family; may be involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation; interacts with unliganded TRs.
TRIM28	Tripartite motif-containing 28 protein, transcription intermediary factor 1-β (TIF1-β) (nuclear corepressor KAP-1)	Mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors; interacts with ESR1 and GR; coactivator of NUR77 (NR4A1); exists in NCoR corepressor complex.

AR, Androgen receptor; GR, glucocorticoid receptor; HDAC, histone deacetylase; PR, progesterone receptor; ROR, retinoid-related orphan receptor.