Table 2.

Analog-induced sst2A receptor internalization

Analog	Half-life (min)	Maximal internalization (% of total)
SS14	4.3 ± 0.7	82.8 ± 1.5
KE108	4.5 ± 0.2	74.2 ± 0.9
SOM230	4.4 ± 0.3	46.0 ± 3.2

The rate of sst2A receptor endocytosis following stimulation of CHO-sst2A cells with 100 nm SS14, 1 μm SOM230, or 1 μm KE108 was measured as described in Fig 2. Values for the half-time and extent of receptor internalization were determined by nonlinear regression analysis of three to seven independent experiments. Data are presented as the mean ± sem. Statistical analysis was carried out using Dunnett's multiple comparison test and showed that maximal internalization with SOM230 (P < 0.01) and KE108 (P < 0.05) both differed significantly from that produced by SS14.