Table 4.
Rates of analog-induced sst2A receptor recycling and dephosphorylation
| Analog | Receptor Recycling (min) | Receptor dephosphorylation |
|
|---|---|---|---|
| Ser341/343 (min) | Thr353/354 (min) | ||
| SS14 | 42.3 ± 7.4 | 6.5 ± 0.5 | 7.9 ± 0.3 |
| KE108 | 10.7 ± 1.9 | 5.8 ± 0.5 | 3.0 ± 0.5 |
| SOM230 | 4.8 ± 2.1 | 5.5 ± 0.5 | 2.7 ± 0.5 |
The rates of sst2A receptor recycling and receptor dephosphorylation were measured as described in Fig. 6 after stimulation of CHO-sst2A cells for 30 min with 100 nm SS14, 1 μm KE108, or 1 μm SOM230. Values for half-times were calculated by nonlinear regression analysis of three to six independent experiments, and data are presented as the mean ± sem.