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. 2011 Mar 31;25(6):1066–1071. doi: 10.1210/me.2010-0460

Fig. 2.

Fig. 2.

TGR5 agonism increases gallbladder (GB) volume. A–C, Gallbladder volume was measured in male wild-type (WT) and Tgr5−/− mice treated for: 2 wk with 0.2% CA in the diet (n = 4–5/group) (A), 30 min with LCA (60 mg/kg) or DMSO control by ip injection (n = 5/group) (B), and 30 min INT-777 (60 mg/kg) or DMSO control by ip injection (n = 5–6/group) (C). D, Male mice were treated with CCK (200 ng/kg) or saline control and INT-777 (60 mg/kg) or DMSO control by ip injection (n = 5/group). Gallbladder volumes were normalized to body weight (B.W.). All data are the mean ± sem. *, P < 0.05; **, P < 0.01; ***, P < 0.001.