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TGR5 regulates bile flow. A, Bile flow rate was measured in male wild-type (WT) and Tgr5−/− mice (n = 6–8/group). B and C, Bile flow rates were measured in male mice 15 min after ip injection of LCA (60 mg/kg) or DMSO control (n = 4/group) (B) or INT-777 (60 mg/kg) or DMSO control (n = 5–6/group) (C). Bile flow rates were normalized to body weight. All data are the mean ± sem. *, P < 0.01. n.s., Not significant.
