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. 2011 Apr 28;25(6):1018–1026. doi: 10.1210/me.2010-0513

Fig. 5.

Fig. 5.

Wnt activity in the normal and bicalutamide-treated adult prostates. A–C, Control prostate samples from P30 TOPGAL-untreated males. A, UGS tissues stained with X-gal in whole mount show strong LacZ activity in the prostate lobes. Prostate tips are indicated with arrowheads. B and C, Sections of untreated ventral prostate lobes at ×20 (A) and ×40 (B) magnification show LacZ-positive cells in the basal prostate epithelium. D–F, In contrast, bicalutamide-treated prostates show LacZ activity in the luminal epithelium. P23 TOPGAL males were given 30 mg/kg·d of Casodex (AstraZeneca) in drinking water for 7 d, then prostates were stained with X-gal in whole mount (D), embedded in paraffin, and sectioned (E and F). Scale bars, 50 μm.