Fig. 1.

SXR^−/− mice develop a lymphoproliferative syndrome that progresses with age. A, SXR^−/− animals develop severe inflammation and acute lymphoproliferations and ultimately develop lymphoma; B, spleens of aged SXR^−/− animals are enlarged, ranging from 0.2–1 g (as compared with 0.1 g for strain- and age-matched control animals); C, hematoxylin- and eosin-stained slides for WT and KO animals indicate inflammation, lymphoproliferation, and disruption of normal architecture in aged SXR KO animals. Original magnification for all panels, ×40.