Fig. 2.

SXR^−/− mice have a lymphoproliferative disorder of B-1a cells. A, B-1a cell markers CD5, B220, and IgM expression as measured in WT and KO spleen (SP). CD5 expression histogram shows IgM-positive cells from both WT and KO spleen. IgM and B220 expression in the spleen of WT and KO animals is shown; IgM^high/B220^intermediate population is indicated in KO panel by gate. B, IgM and CD5 expression in peritoneal lavage (PL) of WT and KO animals. IgM⁺/CD5⁺ population is indicated by gate. B-1a cell percentages per tissue are indicated by bar graph. C, Light chain κ- vs. λ-positive staining as measured by flow cytometry of SP and lymph nodes (LN). D, SXR^−/− mice demonstrate increased spleen to body mass ratio characteristic of lymphoma.