Fig. 3.

SXR is present in lymphatic tissues, and loss of function promotes lymphocyte proliferation. A, SXR mRNA expression as measured by qRT-PCR. All values are shown as percentage of mean liver. B, SXR protein is present in liver (Li), spleen (Sp), lymph node (LN), and thymus (Thy) in WT mice, as measured by Western blot. C, SXR^−/− lymphocytes are proliferative in unstimulated cell culture. The 24- to 96-h time points are shown, as measured by DNA content (CyQuant). Statistical measurements are relative to 24-h KO value.