Table 2.
Efficiency of different mitogens and karyotypes in 18 patients with SMZL.
| Patient | Age | Sample (*) | Score (**) | Karyotype | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TPA | LPS | ODN + IL2 | ||||||||||
| Quality | Proliferation | Efficiency | Quality | Proliferation | Efficiency | Quality | Proliferation | Efficiency | ||||
| 1 | 70 | Pb (21.9) | 3 | 3 | N | 3 | 2 | N | 3 | 3 | N | 46, XY [20] |
| 2 | 78 | BM (38%) | 2 | 3 | N | 2 | 3 | A | 3 | 3 | A | 47, XX, +12 [2]/46,XX [18] |
| 3 | 77 | Pb (7.28) | 0 | 1 | F | 1 | 3 | A | 3 | 3 | A | 47, XY, add(5)(p15),+22 [15]/47, XY, add (5)(p15), del (7)(q22), i(8)(p10), +del (14)(q24) [5] |
| 4 | 75 | BM (35%) | 3 | 3 | N | 3 | 4 | A | 3 | 2 | A | Near tetraploid: 91, XXY, idic (1)(p11), del (11)(q21), add(14)(q32), +mar1, +mar2 [3]/46, XY [17] |
| 5 | 76 | Pb (8.63) | 0 | 1 | F | 0 | 1 | F | 2 | 3 | A | 46, XY, der (3)(p26), del (7)(q32), del (13)(q22) [4]/46, XY [21] |
| 6 | 69 | Pb (34.8) | 0 | 1 | F | 3 | 3 | N | 3 | 3 | N | 46, XY [20] |
| 7 | 55 | Pb (16.1) | 3 | 3 | N | 3 | 2 | A | 3 | 3 | A | 46, XY, t(3;13)(q21;q13), del (11)(q12) [13]/46, XY [7] |
| 8 | 84 | Pb (20) | 0 | 1 | F | 3 | 3 | A | 4 | 3 | A | 46, XX, -9, t(14;19)(q32;q13), +add (14)(q32) [19]/46, XX [1] |
| 9 | 76 | Pb (4.5) | 3 | 3 | A | 3 | 3 | A | 4 | 4 | A | 47, XY, +12 [15]/46, XY [5] |
| 10 | 63 | Pb (NA) | 2 | 4 | N | 2 | 3 | N | 2 | 4 | N | 46, XY [20] |
| 11 | 86 | Pb (6.1) | 3 | 3 | A | 1 | 2 | A | 3 | 3 | A | 46,XX,del(14) (q22) [16]/46,XX [5] |
| 12 | 76 | Spleen | 0 | 1 | F | 0 | 1 | F | 2 | 3 | N | 46, XX [20] |
| 13 | 75 | Pb (23.1) | 3 | 3 | N | 1 | 2 | N | 3 | 4 | A | 48, XY, +12, +15 [5]/46, XY [15] |
| 14 | 83 | BM (30%) | 2 | 3 | N | 2 | 3 | N | 2 | 4 | A | 46, XY, del (3)(p13) [3]/46, XY [17] |
| 15 | 85 | Pb (4.2) | 0 | 1 | F | 3 | 3 | A | 3 | 3 | A | 47, XY, +12, del (14)(q24) [12]/46, XY [8] |
| 16 | 72 | Pb (2.9) | 0 | 1 | F | 0 | 1 | F | 4 | 3 | A | 46, XY, dup (1)(q21q32), del (7)(q32), del (13)(q14q22) [2]/47, XY, del (7)(q32), der (12) t(3;12)(p11;p11), |
| del (13)(q14q22), +mar1 +mar2 [1]/46, XY [17] | ||||||||||||
| 17 | 56 | Pb (4.9) | 3 | 3 | A | 3 | 4 | A | 3 | 3 | A | 46, XY, del (7)(q32) [8]/46, XY [12] |
| 18 | 82 | Pb (7.1) | 3 | 2 | N | 0 | 1 | F | 3 | 3 | A | 47, XX, +3 [4]/46, XX [16] |
*Absolute lymphocyte count × 109/L at the time of cytogenetic investigation, or % BM infiltration, as appropriate. NA: not available.
**See materials and methods for details; A: abnormal, N: normal, and F: failure.