Fig. 1.
Decreased uteroplacental perfusion in animals fed a HFD. Maternal HFD leads to increased uterine artery PI. A, Uterine artery (Uta) PI is 0.74 in a representative control animal. B, The Uta PI is 1.17 in a representative HFD-S animal with a Doppler waveform that demonstrates decreased diastolic flow consistent with increased vascular impedance when compared with A. C, The cQUta normalized to maternal weight was significantly reduced in HFD-R and HFD-S animals when compared with CTR. *, P < 0.05 (one-way ANOVA with Bonferroni's multiple comparison test). D, Uta PI is increased in HFD-S animals when compared with CTR. *, P < 0.05, Student's t test. As a group, HFD (HFD-R + HFD-S) had a significant increase in Uta PI when compared with CTR. *, P < 0.05, Student's t test. E, The cQUV normalized to fetal abdominal circumference was reduced in HFD-S animals when compared with controls. There was no difference in HFD-R animals when compared with controls. *, P < 0.05, one-way ANOVA with Bonferonni's multiple comparison test. F, The umbilical artery (UA) PI was unaffected by diet group. CTR, n = 9; HFD-R, n = 6; HFD-S, n = 9.