Figure 4.

Theta burst firing decreases synaptic integration. A, Theta burst firing modulates the properties of spontaneous synaptic events. Spontaneous synaptic events displayed a range of amplitudes in vivo. B, Several parameters of spontaneous synaptic events are modified after theta burst firing, including amplitude and half-width, depicted in these and cumulative probability plots from a single example. The inter-event interval did not change. C, D, Spontaneous synaptic events occur in bursts in vivo in BLA neurons (baseline) (C). TBF results in a decrease in the average peak amplitude of these bursts of events (post-TBF) (C) and a leftward shift in the distribution of the membrane potential (black line is baseline, gray line is post-TBF) (D). E, This can be accounted for with a postsynaptic mechanism, as there is also a decrease in the summation of αPSPs after TBF.