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. Author manuscript; available in PMC: 2012 May 16.
Published in final edited form as: Chem Res Toxicol. 2011 Apr 21;24(5):744–751. doi: 10.1021/tx200033v

Figure 1. Schematic illustration of the metabolomic strategy for the screening of trapped reactive metabolites.

Figure 1

Xenobiotics were incubated in a reaction system containing enzymes, with or without NADPH and trapping reagents. The incubated samples were analyzed by UPLC-TOFMS. A data matrix was generated by MarkerLynx. Multivariate data analysis (MDA) was then conducted to screen trapped reactive metabolites.