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. Author manuscript; available in PMC: 2012 May 16.
Published in final edited form as: Chem Res Toxicol. 2011 Apr 21;24(5):744–751. doi: 10.1021/tx200033v

Figure 2. GSH-trapped reactive metabolites of PLG.

Figure 2

The method of PLG incubation with HLM is detailed in Materials and Methods. All samples were analyzed by UPLC-TOFMS. (A) Separation of each incubation group in OPLS-DA score plot. The t[1]P and t[2]O values represent the score of each sample in principal component 1 and 2, respectively. (B) Loading S-plot generated by OPLS-DA analysis. The X-axis is a measure of the relative abundance of ions and the Y-axis is a measure of the correlation of each ion to the model. *, in-source fragment. (C) Line score plot of PLG_GS_1 generated by OPLS-DA analysis. (D) The chromatograms and structures of GSH conjugated PLG metabolites.