Fig. 2.

Sterility of RanBPM^−/− males. (A-D) Hematoxylin and Eosin (H&E)-stained sections of testis (A,B) and epididymis (C,D) from wild-type (+/+; A,C) and knockout (−/−; B,D) 6-week-old (6 w) mice. Mutant seminiferous tubules are almost totally devoid of germ cells (B) and spermatozoa are absent in the mutant epididymis (D). Insets show enlarged views of the boxed areas in C and D. Spermatozoa are indicated by arrows. (E,F) At 9 months (9 m) mutant tubules (F) are completely degenerated compared with wild type (E). Scale bars: 100 μm.