Fig. 7.

Atrophy of RanBPM^−/− ovaries. (A-F) Histological analysis of ovary Hematoxylin and Eosin (H&E) sections of wild-type (WT; A,C,E) and mutant (B,D,F) mice at 3 weeks (A,B), 2 months (C,D) and 7 months (E,F). At 3 weeks, ovaries are already atrophied and contain fewer follicles than WT. At 2 months, only a few follicles are present in RanBPM^−/− mice ovaries and by 7 months mutant ovaries are devoid of follicles. Note that the apparent similar size between aged mutant (F) and control (E) ovaries is due to the presence of a large cyst in the mutant. Arrows in E indicate follicles. Scale bars: 500 μm.