Fig. 2.

CRF₁ antagonist treatment to nonhandled rats from P10–17 facilitates spatial learning during the training phase of the Morris watermaze. Data are given as the mean latency in seconds (±se) per trial required to find the submerged platform. A, Performance of handled (n = 11), handled and CRF₁ antagonist-treated (n = 8), nonhandled (n = 15), and nonhandled and CRF₁ antagonist-treated (n = 10) rats on d 1 and 2. B, Comparing naive and vehicle-treated subgroups, spatial learning was not different on all 3 d. Left, Nonhandled (n = 9) and vehicle-treated nonhandled (NH+Veh; n = 6); right, handled rats [naive, n = 8; vehicle treated (H+Veh), n = 3].