Fig. 5.
Infusion of CRF1 antagonist down-regulates CRF mRNA levels in PVN in adult nonhandled rats. Semiquantitative analysis depicting the mean (±se). NH, Nonhandled rats (n = 3); NH+Veh, vehicle-treated nonhandled rats (n = 6); H, handled rats (n = 4); H+Veh, vehicle-treated handled rats (n = 3); NH+Antag, nonhandled rats treated with CRF1 antagonist (n = 5). *, Significantly different from NH and NH+Veh groups, P < 0.05. NH+Antag levels were not significantly different from those in the H groups.