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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Mol Cell Neurosci. 2011 Mar 17;47(1):61–70. doi: 10.1016/j.mcn.2011.03.003

Figure 6. Potentially attenuating effects of cell-cell fusion demonstrated through quantitative analysis of percentage of NIs observed and the number of surviving Purkinje neurons found per section.

Figure 6

A) NIs observed were divided into singular NIs and multiple NIs. In the no-BMT control group, 85.32% of the total NIs counted was single inclusions and 14.7% was multiple inclusions, for the NVV-BMT control group, 88.75% was single inclusions and 11.24% was multiple inclusions, and for the AAV-BMT treatment group, 82.94% was single inclusions and 17.06% was multiple inclusions. B) A significant difference was observed between the treatment and control groups in the percentage of total NIs observed. The AAV-BMT group harbored 23% NIs in the total number of Purkinje neurons counted, while the no-BMT control group had 38% NIs and the NVV-BMT control group contained 42%. (asterisks indicate statistical significance with p<0.05) C) Further more, AAV-BMT treated group was also found to have a higher number of viable Purkinje neurons (749 cells/section) than the no-BMT control group (659 cells/section) or the NVV-BMT control group (727 cells/section). (NIs=nuclear inclusions; BMT=bone marrow transplant; NVV=no viral vector)