Table 3.
Crude rates of recurrent VTE after stopping anticoagulant treatment according to location of initial VTE, length of treatment, and months of follow-up after stopping treatment—all participants
| Length of treatment (months) | Months after stopping treatment | Recurrent episodes of VTE per 100 patient years (95% CI) (events/patient years) | |||
|---|---|---|---|---|---|
| Pulmonary embolism | Proximal DVT | Isolated distal DVT | All participants | ||
| 1 or 1.5 | ≤6 | 43.0 (25.9 to 71.4) (15/35) | 21.9 (15.6 to 30.6) (34/155) | 10.0 (5.9 to 16.9) (14/140) | 19.1 (14.9 to 24.4) (63/330) |
| 7-24 | 8.6 (3.9 to 19.1) (6/70) | 7.2 (4.9 to 10.7) (25/345) | 3.4 (1.9 to 6.4) (10/291) | 5.8 (4.3 to 7.9) (41/706) | |
| 0-24 | 20.1 (13.1 to 30.8) (21/105) | 11.8 (9.1 to 15.2) (59/500) | 5.6 (3.7 to 8.3) (24/431) | 10.0 (8.3 to 12.2) (104/1036) | |
| 3 | ≤6 | 10.8 (6.8 to 17.1) (18/167) | 11.3 (7.9 to 16.0) (31/275) | 4.2 (1.1 to 16.8) (2/48) | 10.4 (7.9 to 13.7) (51/490) |
| 7-24 | 2.9 (1.5 to 5.3) (10/347) | 6.4 (4.5 to 9.0) (33/516) | 2.2 (0.3 to 15.81) (1/45) | 4.8 (3.6 to 6.5) (44/908) | |
| 0-24 | 5.4 (3.8 to 7.9) (28/514) | 8.1 (6.3 to 10.3) (64/791) | 3.2 (1.0 to 10.1) (3/93) | 6.8 (5.6 to 8.3) (95/1398) | |
| 6 | ≤6 | 9.5 (5.3 to 17.2) (11/115) | 10.2 (6.4 to 16.2) (18/176) | 5.1 (1.9 to 13.5) (4/79) | 8.9 (6.3 to 12.5) (33/370) |
| 7-24 | 5.2 (2.9 to 9.3) (11/213) | 8.1 (5.5 to 12.0) (26/319) | 3.7 (1.8 to 7.3) (8/219) | 6.0 (4.5 to 8.0) (45/751) | |
| 0-24 | 6.7 (4.4 to 10.2) (22/328) | 8.9 (6.6 to 11.9) (44/495) | 4.0 (2.3 to 7.1) (12/298) | 7.0 (5.6 to 8.7) (78/1121) | |
| 12 or 27 | ≤6 | 11.4 (5.4 to 23.8) (7/62) | 10.7 (5.6 to 20.5) (9/84) | 0.0 (0/1.1) | 10.9 (6.7 to 17.8) (16/147) |
| 7-24 | 2.9 (1.1 to 7.8) (4/136) | 8.1 (4.9 to 13.4) (15/185) | NA | 5.9 (3.8 to 9.3) (19/321) | |
| 0-24 | 5.6 (3.1 to 10.0) (11/198) | 8.9 (6.0 to 13.3) (24/269) | 0.0 (0/1.1) | 7.5 (5.4 to 10.4) (35/468) | |
| All | ≤6 | 13.5 (10.2 to 17.7) (51/379) | 13.3 (10.9 to 16.3) (92/691) | 7.5 (4.8 to 11.6) (20/267) | 12.2 (10.5 to 14.2) (163/1337) |
| 7-24 | 4.0 (2.8 to 5.8) (31/766) | 7.3 (6.0 to 8.8) (99/1365) | 3.4 (2.2 to 5.4) (19/555) | 5.5 (4.7 to 6.5) (149/2686) | |
| 0-24 | 7.2 (5.8 to 8.9) (82/1145) | 9.3 (8.1 to 10.7) (191/2056) | 4.7 (3.5 to 6.5) (39/822) | 7.8 (6.9 to 8.7) (312/4023) | |
DVT=deep vein thrombosis; NA=not applicable; VTE=venous thromboembolism.