Figure 6. IFN-α affects T cell activation.

(A) CD4⁺ T cells were stimulated with SEB and IFN-α as indicated. Proliferation was measured by thymidine incorporation. (B) Naive B cells were cultured in the presence or absence of IFN-α or CpG C for 4 days, pulsed with SEB for 1 h before being added at a ratio of 1:10 to autologous CD4⁺ T cells. Production of effector cytokines by CD4⁺ T cells was measured by intracellular flow cytometry. (C) Compiled data from six donors are shown.