Figure 3. Biodistribution of DOTA-PEGn-AVP04-50 conjugates in athymic mice bearing LS-174T xenografts.
The biodistribution of the constructs was determined in athymic mice bearing LS-174T xenografts as described in Methods. A. 111In-DOTA-AVP04-50 (PEGn= 0). B. 111In-DOTA-PEG12-AVP04-50 (PEGn= 12). C. 111In-DOTA-PEG24-AVP04-50 (PEGn= 24). D. 111In-DOTA-PEG48-AVP04-50 (PEGn= 48). Key: yellow= kidney, dark blue= tumor, red= blood, green= liver, light blue= lungs, magenta= spleen, orange= carcass.