Table 1.
Clinical characteristics of autopsy and TLE individuals
|
Parameter |
Autopsy (n = 10) |
Temporal lobe epilepsy Non-HS (n = 10) |
Hippocampal sclerosis (n = 17) |
p value |
|---|---|---|---|---|
| Age at tissue harvest | 45 ± 5.2 | 34.9 ± 2.4 | 34.2 ± 2.3 | p > 0.05 for all pair groups |
| (years ± SEM) (range) | (21-70) | (26-49) | (18-49) | pair groups |
| Age of seizure onset | NA | 19.6 ± 2.1 | 14.5 ± 3.1 | p = 0.25 |
| (years ± SEM) (range) | (10-32) | (3-40) | ||
| Seizure durationa | NA | 15.3 ± 3 | 18.8 ± 2.4 | p = 0.38 |
| (years ± SEM) (range) | (2-37) | (4-35) | ||
| Initial precipitating event | NA | 2 | 13 (9 prolonged seizures) | |
| Gender (male:female) | 5:5 | 5:5 | 11:6 | |
| Hippocampus side (right:left)
|
4:6
|
7:3
|
10:7
|
|
NA, Not applicable; p values computed using ANOVA (age at harvest) or Student's t test (age of seizure onset and duration of seizures).
a
Seizure duration calculated as time (in years) between onset of habitual seizures and hippocampal resection.