Table 2.
Selected functional genomics studies in higher organism systems.
| System (organism) | Outcome | Reference |
|---|---|---|
| shRNA bar code (human) | Identification of genes whose suppression confers resistance to p53-induced growth arrest | [86] |
| shRNA bar code (human) | Identification of genes whose suppression confers resistance to p53-induced growth arrest | [87] |
| shRNA bar code (human) | Identification of genes whose suppression confers resistance to Herceptin | [88] |
| siRNA (human) | Identification of genes required for paclitaxel tolerance | [89] |
| RNAi (C. elegans) | Identification of genes involved in the toxicogenesis of a polychlorinated biphenyl (PCB) | [82] |
| shRNA (human) | Identification of radiation susceptibility genes | [90] |
| siRNA (human) | Identification of genes required for stress resistance | [91] |
| shRNA bar code (human) | Identification of genes required for cancer proliferation | [92] |
| shRNA (human) | Identification of genes required for induction of apoptosis | [79] |
| RNAi (zebrafish) | Characterization of novel human platelet proteins | [93] |
| siRNA (human) | Identification of genes whose suppression confers resistance to epirubicin | [94] |
| Mutagenized haploid cells (human) | Identification of diptheria toxin pathway genes | [85] |
| RNAi (D. melanogaster) | Identification of modifiers of mutant Huntingtin aggregate formation | [95] |