Table 1.

Table 1. Multiple mutations and lys2 mutation spectra resulting from UV irradiation of cdc13-1 yeast strains.

Genotype1	Number of mutations in a mutant						Total # of mutants	D2 (mut/kb)	Indel.3	Compl.4	Sub., Py5		Sub., Pu6		Total # of mutations
	1	2	3	4	5	6					T	C	A	G
WT	7	16	5	4	1	1	34	0.31	19	5	34	17	6	0	81
rad30Δ	6	9	5	1	0	1	22	0.28	6	6	20	14	1	2	49

¹The data for the Rad⁺ (WT) strain are from reference ²⁹, the data for rad30Δ strain are given in Supplemental Table 1.

²D (mut/kb), densities of mutations in the 4396 nt LYS2 reporter were calculated as described in reference ⁴⁵ using the formula: D=(n₂+ 2n₃+ 3n₄ + 4n₅ + 5n₆)/(M − 4.396), where n_x is the observed number of mutants with x mutations and M is the total number of mutants. Calculations were made on the assumptions that (1) the vast majority of mutants originate from the hypermutable fraction; and (2) within this fraction individual mutations occur with equal probability in every cell.

³Indel: Small insertions and deletions.

⁴Comp: Complex mutations.

^5,6Sub Py and Sub Pu: Number of simple base substitutions in pyrimidine (Py: T or C) or purine (Pu: A or G) nucleotides in the non-resected strand.