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. 2011 May 4;31(18):6741–6749. doi: 10.1523/JNEUROSCI.5883-10.2011

Figure 5.

Figure 5.

Increased coexpression of Ret and TrkC in DRG neurons in Wnt1-Cre; Shox2flox/flox mice. A, Representative results of two-color in situ hybridization using TrkB (red) and TrkC (green) probes at E18.5. Arrows indicate neurons in the DRGs that are positive for both receptors. B, Representative results of two-color in situ hybridization using Ret (red) and TrkC (green) probes at E18.5. Arrows indicate cell bodies in the DRGs that are positive for both receptors. C, Quantification of the average number (per unit area) of TrkB/TrkC-double-positive neurons revealed no significant difference between the control and Shox2-deleted mice. D, Quantification of the average number (per unit area) of Ret/TrkC-double-positive neurons showed a significant increase in the Shox2-deleted versus control DRGs. E, Representative images of two-color in situ hybridization results with Parvalbumin (red) and Ret (green) probes at P0. F, Representative images of two-color in situ hybridization results with MrgD (red) and TrkC (green) probes at P0. *p < 0.01, **p < 0.001. Error bars represent ± SEM. Scale bars, 100 μm.