TABLE 1.

Pharmacokinetic parameters for orally or intravenously administered LVS in IE-Cpr-null and WT mice

Data from Fig. 1, B and D, were used for the determination of pharmacokinetic parameters. Adult female IE-Cpr-null and age-matched WT mice (5–6 per group) were given a single dose of LVS, via oral gavage, at 25 mg/kg, or via intravenous injection, at 2.5 mg/kg. Values represent means ± S.D. (n = 5–6).

Route	Strain	Tmax	Cmax	t1/2	AUC0-∞	CL/F
		min	μg/ml	min	min · μg/ml	ml/min
p.o.	WT	27 ± 7	0.3 ± 0.1	50 ± 9	23.5 ± 5.1	23.0 ± 4.6
	IE-Cpr-null	30 ± 0	0.8 ± 0.1a	68 ± 9b	76.4 ± 5.1a	7.0 ± 0.4a
i.v.	WT	10 ± 0	1.3 ± 0.1	17 ± 4	51.5 ± 4.4	1.0 ± 0.7
	IE-Cpr-null	10 ± 0	1.4 ± 0.1	19 ± 4	53.5 ± 3.6	1.0 ± 0.1

CL/F, apparent clearance.

^a P < 0.01 and

^b P < 0.05, compared to the corresponding WT group (Student's t test).