TABLE 1.
Covalent binding of SCH 66712 to CYP2D6
| Radiolabeled Protein |
|||
|---|---|---|---|
| +NADPH | −NADPH | NADPH-Dependent | |
| nmol SCH 66712/nmol of total CYP2D6 | |||
| Precipitation assay (n = 3) | 3.15 | 1.95 | 1.20 |
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