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Model illustrating client protein reactivation by the collaborative activities of Hsp90Ec and the DnaK system. (A) First, the DnaK system (DnaK, DnaJ, or CbpA and GrpE) interacts with an inactive or denatured substrate and initiates the ATP-dependent remodeling process. (B) Then, Hsp90Ec interacts with DnaK and the substrate, and together in a nucleotide-dependent manner the two chaperones promote remodeling. (C) The substrate is released by the chaperones.
