Fig. 4.

For cells of the B15 haplotype, translocation specificity is the same as the peptide motif of the single class I molecule. Translocation of labeled B15 indicator peptide KRYNASAY was inhibited by individual nonradioactive peptides with amino acid substitutions (in single letter code) in positions 1 (A), 2 (B), and 8 (C). (D) Model of translocation of peptides with specificity of the single (BF2) class I molecule in the B15 haplotype. Plus sign, minus sign, and empty circles indicate positive, negative, and hydrophobic residues; R, arginine; Y, tyrosine.