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A model depicting the effect of RS phosphorylation in the E complex formation. Phosphorylation of the SRSF1 RS domain, mediated by the sequential actions of SRPK1 and CLK/STY, induces the dissociation of the RS from its RRM. Free SRSF1 (RRM) recruits U1 snRNP to the 5′SS through RRM-RRM interaction between SRSF1 and U1-70K. Released pp-RS domain interacts to the splicing factors bound to BPS/pY/3′SS to stabilize the E complex.
