Fig. 4.
RO5166017 reverses stress-induced hyperthermia (SIH). (A) In NMRI mice, RO5166017 significantly reversed the SIH (dT) at doses 0.1 and 0.3 mg/kg without affecting basal Tb (Fig. S4). At 1 mg/kg, the decrease of dT was attributed to a nonspecific effect on Tb (Fig. S4A). The diagram combines the data of two experiments. ***P < 0.001, **P < 0.01 vs. Veh (n = 8–16 per group). (B) RO5166017 (0.1 mg/kg) failed to decrease dT in Taar1−/− C57BL/6 mice in contrast to their WT littermates. In both genotypes, basal Tb was not affected (Fig. S4A). **P < 0.01 vs. WT/Veh (n = 8–10 per group). Numbers on the x axes are oral doses of RO5166017 in mg/kg. Veh, vehicle. All data represent the mean ± SEM.