Fig. 4.

Exposure to Δ⁹-THC enhances forskolin-evoked adenylyl cyclase activity in the NAcc. Data are shown as group mean (± S.E.M.) adenylyl cyclase activity (nanomoles/minute/milligram of protein) evoked by increasing concentrations of forskolin (0–100 μM) in assays conducted 2 weeks after exposure to Δ⁹-THC (vehicle or 3.0 mg/kg i.p.). The line drawing (adapted from Paxinos and Watson, 1997) depicts the caudal surface of a coronal section extending +1.2 to +2.2 mm from bregma and illustrates the region corresponding to the NAcc that was dissected bilaterally for the assay (cross-hatched areas). **, p < 0.01; ***, p < 0.001; significantly greater than vehicle as determined by post hoc LSD comparisons after between-within ANOVA (n = 6–7/group).