TABLE 2.
Behavior | Δ9-THC Dose |
|||||
---|---|---|---|---|---|---|
0 mg/kg | 0.4 mg/kg | 0.75 mg/kg | 1.5 mg/kg | 3 mg/kg | 6 mg/kg | |
Day 1 | ||||||
Epoch 1 (0–30 min) | ||||||
Sniffing | 24.75 ± 2.50 | 20.75 ± 0.85 | 20.00 ± 1.58 | 22.00 ± 1.96 | 22.25 ± 0.95 | 22.75 ± 4.33 |
Walking | 10.25 ± 1.03 | 10.00 ± 0.58 | 10.25 ± 0.48 | 11.25 ± 0.25 | 13.00 ± 0.58 | 11.50 ± 1.85 |
Grooming | 2.00 ± 0.91 | 0.50 ± 0.29 | 1.25 ± 0.48 | 0.75 ± 0.48 | 1.00 ± 0.41 | 0.00 ± 0.00** |
Motionless | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.25 ± 0.25 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
Epoch 2 (45–75 min) | ||||||
Sniffing | 7.00 ± 1.29 | 16.50 ± 3.93* | 17.25 ± 1.80** | 15.25 ± 3.59* | 20.00 ± 2.42** | 21.75 ± 0.48*** |
Walking | 2.25 ± 1.11 | 6.50 ± 1.04** | 8.00 ± 0.91*** | 5.25 ± 0.85 | 7.25 ± 1.38** | 9.00 ± 0.71*** |
Grooming | 6.50 ± 2.10 | 2.50 ± 0.87* | 2.00 ± 0.71* | 1.50 ± 0.87** | 1.75 ± 1.44** | 0.00 ± 0.00*** |
Motionless | 5.75 ± 2.17 | 2.25 ± 0.87 | 0.25 ± 0.25** | 2.50 ± 1.26 | 0.75 ± 0.48** | 0.00 ± 0.00** |
Epoch 3 (90–120 min) | ||||||
Sniffing | 11.25 ± 3.82 | 4.50 ± 1.55 | 15.25 ± 5.76 | 15.50 ± 3.12 | 11.25 ± 3.33 | 12.00 ± 2.86 |
Walking | 4.75 ± 1.89 | 0.75 ± 0.48 | 3.00 ± 1.58 | 5.50 ± 0.87 | 3.75 ± 1.55 | 4.75 ± 1.32 |
Grooming | 1.00 ± 0.58 | 0.75 ± 0.48 | 1.75 ± 0.75 | 1.50 ± 0.29 | 0.75 ± 0.48 | 0.50 ± 0.50 |
Motionless | 7.00 ± 2.48 | 12.50 ± 1.04 | 7.25 ± 0.75 | 3.75 ± 1.44 | 8.00 ± 2.08 | 6.00 ± 1.47 |
Day 5 | ||||||
Epoch 1 (0–30 min) | ||||||
Sniffing | 10.50 ± 1.85 | 15.00 ± 2.80 | 15.05 ± 3.12 | 20.25 ± 0.25** | 18.50 ± 0.87* | 18.25 ± 2.78* |
Walking | 5.75 ± 1.32 | 6.75 ± 1.65 | 7.75 ± 1.89 | 8.75 ± 1.03 | 8.50 ± 0.65 | 6.00 ± 1.29 |
Grooming | 3.50 ± 1.19 | 6.25 ± 0.75 | 4.50 ± 1.55 | 2.50 ± 0.29 | 2.50 ± 1.19 | 0.75 ± 0.48 |
Motionless | 5.25 ± 0.85 | 2.00 ± 1.22** | 4.00 ± 1.00 | 0.75 ± 0.75*** | 1.50 ± 0.50** | 0.50 ± 0.50*** |
Epoch 2 (45–75 min) | ||||||
Sniffing | 5.25 ± 1.65 | 8.50 ± 3.28 | 10.50 ± 1.85 | 12.75 ± 0.63* | 14.00 ± 3.08** | 7.25 ± 1.32 |
Walking | 2.00 ± 0.58 | 2.50 ± 1.04 | 2.50 ± 0.29 | 6.50 ± 1.04** | 6.00 ± 0.71** | 3.50 ± 1.32 |
Grooming | 3.25 ± 0.75 | 3.25 ± 1.60 | 2.75 ± 1.11 | 2.50 ± 0.96 | 2.25 ± 0.48 | 0.00 ± 0.00** |
Motionless | 8.00 ± 2.12 | 7.25 ± 2.66 | 6.75 ± 1.03 | 4.00 ± 1.22 | 3.50 ± 1.71 | 3.00 ± 1.22 |
Epoch 3 (90–120 min) | ||||||
Sniffing | 7.25 ± 0.63 | 5.00 ± 2.80 | 4.50 ± 1.66 | 7.25 ± 2.69 | 3.50 ± 1.89 | 4.75 ± 2.50 |
Walking | 2.75 ± 1.03 | 2.25 ± 0.95 | 1.25 ± 0.63 | 3.50 ± 1.04 | 2.00 ± 1.22 | 2.25 ± 1.32 |
Grooming | 3.25 ± 0.75 | 2.75 ± 1.03 | 1.50 ± 0.65 | 0.75 ± 0.48* | 1.00 ± 0.71* | 0.00 ± 0.00** |
Motionless | 6.00 ± 1.47 | 8.25 ± 1.80 | 10.50 ± 1.26 | 8.25 ± 2.75 | 11.25 ± 1.55 | 9.25 ± 2.32 |
P < 0.05;
P < 0.01;
P < 0.001 compared with 0 mg/kg.