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. 2011 Jun;337(3):755–765. doi: 10.1124/jpet.111.179416

Fig. 2.

Fig. 2.

DA lesion, l-DOPA, and (±)propranolol alter the transcription of PPE, PPD, and PPT mRNA in the striatum. Hemiparkinsonian rats (n = 11 per group) were given (±)propranolol (VEH, 5 or 20 mg/kg) 5 min before l-DOPA (6 mg/kg) every day for 16 days in a between-subjects design. Rats were killed by decapitation 2 h after final l-DOPA injection on day 16, and the dorsal striata from the lesioned and nonlesioned sides were dissected for subsequent RT-PCR analysis. Bars express percentage change in expression compared with control (unlesioned striatum treated with l-DOPA) for PPE (A), PPD (B), and PPT (C) mRNA expression. Effects were determined using a 2 × 3 (lesion by treatment) mixed model ANOVA followed by post hoc tests. *, p < 0.05, **, p < 0.01 VEH+Intact versus VEH+Lesion; †, p < 0.05, ††, p < 0.01 VEH+Lesion versus (±)PRO5+Lesion.