Fig. 1.
Effect of phospho-ibuprofen on colon cancer cell growth in vitro and in vivo. Top, IC50 values for colon cancer cells treated with PI or ibuprofen for 24 h. Bottom, PI inhibits the growth of SW480 human colon cancer xenografts in nude mice. The study was performed as described under Materials and Methods. The doses of ibuprofen (125 mg/kg) and PI (225 mg/kg) are equimolar. The structure of PI is also shown; the shaded part of the molecule corresponds to conventional ibuprofen. Values are mean ± S.E.M. *, p ≤ 0.05 compared with the corresponding control value.