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PI metabolism in vitro and in vivo. PI can be metabolized through three distinct pathways: 1) oxidation to form 1-OH-PI, 2) oxidation to form carboxyl-PI, or 3) hydrolysis to form ibuprofen, which, in turn, can be metabolized through: 1) glucuronidation to form ibuprofen glucuronide, 2) oxidation to form 2-OH-ibuprofen, or 3) oxidation to form carboxyl-ibuprofen.
