TABLE 2.
Pharmacokinetic parameters of phospho-ibuprofen (400 mg/kg) and ibuprofen (200 mg/kg) in mice
The doses of PI and ibuprofen are equimolar. Experiments were done independently three times; values were generally within 15%.
| Drug Administered | Measurement |
||||
|---|---|---|---|---|---|
| Cmax | Tmax | Elimination t1/2 | AUC0–24h | Sum of AUC0–24h | |
| μM | h | μM × h | |||
| Phospho-ibuprofen | |||||
| Ibuprofen | 530 | 1.0 | 7.7 | 1816 | 2963 |
| 1-OH-ibuprofen | 28 | 2.0 | N.D. | 74 | |
| 2-OH-ibuprofen | 77 | 2.0 | N.D. | 193 | |
| Carboxyl-ibuprofen | 16 | 2.0 | N.D. | 48 | |
| Ibuprofen glucuronide | 215 | 2.0 | 5.3 | 832 | |
| Ibuprofen | |||||
| Ibuprofen | 932 | 0.5 | 12.8 | 4146 | 6437 |
| 1-OH-ibuprofen | 5 | 0.5 | N.D. | 11 | |
| 2-OH-ibuprofen | 83 | 2.0 | N.D. | 572 | |
| Carboxyl-ibuprofen | 81 | 0.5 | 10.0 | 311 | |
| Ibuprofen glucuronide | 274 | 0.5 | 6.3 | 1398 | |
N.D., not determined.