TABLE 3.
PI | 1-OH-PI | Carboxyl-PI | Ibuprofen | 1-OH-Ibuprofen | 2-OH-Ibuprofen | Carboxyl-Ibuprofen | Ibuprofen Glucuronide | |
---|---|---|---|---|---|---|---|---|
pmol/mg protein | ||||||||
Liver | 82 | 22 | 1013 | 739 | 19 | 33 | 13 | 408 |
Heart | 101 | N.D. | N.D. | 2409 | 34 | 96 | N.D. | 55 |
Kidney | 121 | N.D. | N.D. | 1946 | 75 | 220 | 104 | 322 |
Stomach | 421 | N.D. | N.D. | 462 | N.D. | N.D. | N.D. | N.D. |
Small intestine | 521 | N.D. | 36 | 913 | N.D. | N.D. | N.D. | 50 |
Colon | 414 | N.D. | 20 | 431 | N.D. | N.D. | N.D. | 64 |
Blood* | N.D. | N.D. | N.D. | 530 | 24 | 60 | 10 | 121 |
N.D., not detected.
Metabolite levels in the blood were expressed as μM in plasma.