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. 2011 Jun;25(6):2031–2039. doi: 10.1096/fj.10-167056

Figure 1.

Figure 1.

Gross phenotype of ob/ob-klotho double mutants. Top panel: gross appearance (littermates) of WT, klotho−/−, ob/ob, and ob/ob-klotho DKO mice at 9 wk of age. Note that compared to the ob/ob mouse, the ob/ob-klotho DKO mice mouse is significantly smaller in size. Bottom panel: body weight chart of WT (n=24), klotho−/− (n=34), ob/ob (n=33), and ob/ob-klotho DKO (n=25) mice, showing that ob/ob-klotho DKO mice are significantly smaller than ob/ob mice. These observations suggest that inactivation of klotho function in ob/ob mice can reduce obesity in DKO mice. Statistical analysis of each time point is provided in Supplemental Fig. S1A. *P < 0.0001 vs. ob/ob mice; §P < 0.0001 vs. DKO mice from 11 wk onward.