Figure 2.

Fat distribution of ob/ob-klotho double mutants. Fat weight chart of WT, klotho^−/−, ob/ob, and ob/ob-klotho DKO mice. Only male mice were used to calculate fat weight. Analyses of retroperitoneal, mesenteric, and epididymal fat tissue weight suggest that ob/ob mice have significantly increased accumulation of fat tissue, compared to their WT counterparts. Inactivating klotho function from ob/ob mice markedly reduced fat accumulation in ob/ob-klotho DKO mice. *P < 0.001 vs. WT; ^#P < 0.001 vs. WT; ^¶P < 0.01 vs. ob/ob.