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. 2011 Jun;25(6):2031–2039. doi: 10.1096/fj.10-167056

Figure 4.

Figure 4.

Analysis of liver of ob/ob-klotho double mutants. Left panels: microscopic features of liver sections prepared from WT, klotho−/−, ob/ob, and ob/ob-klotho DKO mice at 9 wk of age, showing abnormal fat accumulation in the liver of ob/ob mice. No such features of steatosis are seen in the liver sections prepared from ob/ob-klotho DKO mice. In addition to the massive fatty changes of the liver, focal inflammatory infiltrates are also noted in the liver sections prepared from ob/ob mice (H&E staining, ×40). Right panel: liver weight chart for WT, klotho−/−, ob/ob, and ob/ob-klotho DKO mice at 9 wk of age. Note that compared to the increased liver weight in ob/ob mice, the ob/ob-klotho DKO mice have significantly lower liver weight and are similar to klotho−/− mice. *P < 0.01 vs. WT; #P < 0.01 vs. WT; P < 0.01 vs. ob/ob.