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. 2011 Jun;25(6):2031–2039. doi: 10.1096/fj.10-167056

Figure 5.

Figure 5.

Measurements of serum cholesterol and triglyceride levels. Left panel: compared to WT mice (n=8; 158.2±9 mg/dl), serum cholesterol levels are markedly increased in ob/ob mice (n=10; 217.9±7 mg/dl). In ob/ob-klotho DKO mice (n=12; 205±15 mg/dl), serum cholesterol levels are comparable to those of ob/ob mice. Serum cholesterol levels in klotho−/− mice (n=12) are 169.4 ± 5 mg/dl. #P < 0.001 vs. WT; P<0.05 vs. WT. Right panel: compared to WT mice (n=15; 105.6±5 mg/dl), serum triglyceride levels are are significantly increased in ob/ob mice (n=5; 207.5±11 mg/dl). Similar to the ob/ob mice, serum triglyceride levels are also high in ob/ob-klotho DKO mice (n=15; 151.5±9 mg/dl). Serum triglyceride levels in klotho−/− mice (n=11; 109.5±6 mg/dl) are similar to their WT counterparts. #P < 0.001 vs. WT; P < 0.01 vs. WT.