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. 2011 Jun;25(6):1887–1893. doi: 10.1096/fj.10-175281

Figure 4.

Figure 4.

Islet size and area are significantly reduced in obese Cmah-null mice. A) Immunohistochemical analysis of pancreata using antibody specific for Neu5Gc in HFD-fed mice. Images are representative. B) Pancreatic islet sections from HFD-fed Cmah-null and WT mice analyzed by fluorescence microscopy for insulin (green) and glucagon (red). Images are representative. C) Islet area, expressed as a percentage of total pancreatic area, in NCD-fed and HFD-fed mice (n=4–6 mice/group). D) Mean islet size in NCD-fed and HFD-fed Cmah-null and WT mice (n=4–5 mice/group). E) Islet numbers, normalized for pancreatic area, in NCD-fed and HFD-fed mice (n=4–6 mice/group). Data are represented as means ± se. *P < 0.05, #P < 0.01, ∧P < 0.005.