Skip to main content
. 2011 Jun;25(6):2082–2091. doi: 10.1096/fj.10-176891

Figure 4.

Figure 4.

ATP-stimulated microglial migration is apoE dependent. A) Basal migration of wild-type and apoE−/− microglia was similar, although 300 μM ATP was less effective at stimulating migration of apoE−/− microglia in a Boyden chamber assembly. ATP-stimulated migration of wild-type microglia was RAP independent (1 μM). Data are expressed as percentage of wild-type basal migration; n = 9–15 (i.e., 3–5 independent experiments performed in triplicate). ***P < 0.001; #P < 0.001 vs. basal wild-type; §P < 0.001 vs. basal knockout; ANOVA with Bonferroni multiple comparison test. B) ATP-stimulated migration of wild-type and apoE−/− microglia is dose dependent. Data are expressed as the percentage of the maximum wild-type response to ATP; n = 9–12 (i.e., 3–4 independent experiments were performed in triplicate).