Table 1.

ApoE-dependent microglia chemotaxis to C5a is modulated by human ApoE genetic isoforms

Genotype	C5a
	EC50 (nM)	Maximum response (% of max)
Wild-type	2 ± 1.3	100 ± 8
apoE−/−	0.8 ± 1.8	41.7 ± 6.4*
apoE2	2.3 ± 1.2	44.5 ± 7.3#
apoE3	1.1 ± 0.4	100 ± 6.5
apoE4	4.1 ± 3	51.3 ± 4.8†

^*P < 0.001 vs. wild-type maximum response;

^#P < 0.001 vs. apoE3 maximum response; unpaired t test.