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. 2011 Jun;25(6):1844–1855. doi: 10.1096/fj.10-169797

Figure 3.

Figure 3.

Partial or complete loss of AGS3 impairs renal tubular recovery following unilateral IRI in mice. Representative H&E stained sections of the renal cortex and outer medulla from Gpsm1+/+ (A–J) and Gpsm1−/− mice (K–T) 7 d following sham operation (A–E, K–O) or unilateral IRI (F–J, P–T). Diluted tubules were found in the cortex and outer medulla in the IRI mouse kidneys with the genotypes Gpsm1−/− (asterisks; P–T) and Gpsm1+/− (not shown), but not in either the uninjured Gpsm1−/− kidneys (K–O) or the normal Gpsm1+/+ kidneys with IRI (F–J) or without IRI (A–E). Hypernucleated renal tubules (pound sign; H, J) in the cortex and outer medullary region were found in the Gpsm1+/+ mice 7 d following IRI. In contrast, tubules with casts (Ca; T) or thinned epithelium (arrowheads; R, T) were frequently noted in Gpsm1−/− (P–T) and Gpsm1+/− (not shown) kidneys 7 d postinjury. Original view: ×10 (A, F, K, P); ×20 (B, D, G, I, L, N, Q, S); ×40 (C, E, H, J, M, O, R, and T). Scale bars = 50 μm.