Figure 4.

AGS3 expression and morphometric analysis of kidney injury following unilateral IRI in mice. Morphometric analysis was performed on histological sections obtained from the uninjured (Uninj) and IRI kidneys at 7 d following ischemia. A, B) Changes in outer medullary (A) and total kidney tubular injury (B) were quantified by histological analysis of H&E kidney sections. *P < 0.001 vs. all other groups; **P < 0.001 vs. both uninjured groups. C) Tubular epithelial cell density was histologically quantified using H&E sections from uninjured and IRI-treated kidneys. *P < 0.001 vs. IRI-treated AGS3-deficient group. n = 6–8 mice/group, as indicated on bars.