Table 4.
Overall Comparison of Nine Plasma Products (Analytes) Between 60 HIV-1-Seropositive and 20 Seronegative Youth
| |
Visit 1 resultsa |
Visit 2 resultsa |
||||
|---|---|---|---|---|---|---|
| Analytes | HIV+youth | HIV−youth | p value | HIV+youth | HIV−youth | p value |
| IL-10 | 2.4 (1.6–2.8) | 1.3 (0.8–1.9) | <0.001 | 2.1 (1.4–3.3) | 2.0 (1.3–2.7) | 0.48 |
| IL-18 | 332 (261–403) | 135 (101–167) | <0.0001 | 329 (251–428) | 145 (110–192) | <0.0001 |
| Soluble CD30 | 2.7 (1.8–3.8) | 1.0 (0.8–1.3) | <0.0001 | 2.1 (1.6–4.0) | 1.1 (0.9–1.6) | <0.0001 |
| Eotaxin/CCL11 | 88 (61–132) | 20 (15–48) | <0.0001 | 86 (61–133) | 23 (12–40) | <0.0001 |
| MIP-1α | 61.5 (52.3–68.9) | <6.2 | NA | 66.2 (54.5–72.4) | <6.2 | NA |
| MIP-1β | 48 (38–62) | 38 (29–68) | 0.21 | 47 (40–56) | 39 (31–78) | 0.27 |
| RANTES/CCL5 | 14.3 (5.2–39.9) | 26.5 (4.8–57.9) | 0.29 | 14.8 (5.6–37.4) | 14.9 (7.0–50.9) | 0.61 |
| SDF-1β/CXCL12 | 1220 (916–1847) | 310 (142–360) | <0.0001 | 1277 (924–1808) | 253 (151–402) | <0.0001 |
| C-reactive protein (CRP) | 1421 (540–3368) | 117 (23–190) | <0.0001 | 943 (482–3440) | 127 (27–1340) | <0.001 |
a
Concentrations are shown in pg/ml for all analytes except soluble CD30, RANTES/CCL5, and CRP (in ng/ml). The median and interquartile range (IQR) are shown for each analyte and p values are based on Wilcoxon U-tests (NA, not applicable when most values are below the lower limit of detection).