Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Feb 7;192(3):481–495. doi: 10.1083/jcb.201004016

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 Sen et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 5. — Synergy between Smn and FGF signaling regulates NMJ morphology. (A) Wild-type NMJ derived from larval muscle 4. how24BGAL4 expresses GAL4 predominantly in the mesoderm (muscles). (B) Reduction in NMJ size resulting from muscle-specific (how24BGAL4) reduction of Smn (UAS-Smn-RNAi^C24). (C) Heterozygotes carrying the null allele htl^AB42 show no effect on the number of synaptic boutons. (D) Reduction in NMJ size in how24BGAL4 UAS-Smn-RNAi^C24/htl^AB42. (E) how24BGAL4; btl^dev1/+ animals do not show any significant effects on the NMJ. (F) how24BGAL4 UAS-Smn-RNAi^C24/btl^dev1 transheterozygous animals have reduced synapses. (G) Quantitation of bouton number/muscle in animals of indicated genotypes, normalized per muscle surface area (MSA) as a percentage of wild type (WT). how24BGAL4/+ is used as control. The ANOVA multiple comparison test was used for statistical analysis of the bouton number/muscle. P ≤ 0.05. Bar, 50 µm. n = 40. All preparations were stained with anti-HRP (red) and anti-Dlg (green). The muscle nucleus was labeled using DAPI.